CB Brandon Stephens vs. WR Keenan Allen

Stephens is coming off a stellar game in which he held the Bengals' Ja'Marr Chase to just two catches for 12 yards. Allen leads the league in receptions (83) and targets (113). The Chargers offense often runs through him. Allen lines up all over the formation, so it will be interesting to see how much Stephens follows him or whether the Ravens rotate coverages.

S Kyle Hamilton vs. QB Justin Herbert

The Ravens must mix up the picture on Herbert, who is one of the league's strongest-armed quarterbacks and can be extremely accurate. Hamilton is one of the keys to the Ravens' disguises and can also be utilized to put pressure on the Chargers quarterback.

LB Patrick Queen vs. RB Austin Ekeler

Ekeler is Herbert's other top weapon, especially as a receiver out of the backfield. The Ravens' linebackers have been good in coverage this year, and Ekeler will be one of their toughest tests. Despite missing three games, he's still second on the team in receptions (24) for 254 yards.

TE Isaiah Likely vs. SS Derwin James Jr.

It will be Likely's first game stepping in for Mark Andrews with the Ravens' star tight end sidelined by a likely season-ending ankle injury. He'll often be going against on the league's top safeties in three-time Pro Bowler James, who, like Hamilton, is a versatile weapon in the Chargers' defense.

OT Ronnie Stanley vs. OLB Khalil Mack

Stanley may return to action from his knee injury after practicing two days this week. If not, it will be Patrick Mekari again at left tackle. Whoever it is, they'll have their hands full with Mack, who has the fifth-most sacks in the league (11). Mack mostly wins with power, so the Ravens will have to bring a strong base.