LT Ronnie Stanley vs. DE Aidan Hutchinson

Hutchinson leads the Lions with 4.5 sacks and is one of the more disruptive forces in the league. Hutchinson came up under Ravens Defensive Coordinator Mike Macdonald at Michigan before becoming the No. 2-overall pick last year. Stanley is coming off his best game of the year.

S Kyle Hamilton vs. TE Sam LaPorta

LaPorta has the third-most receiving yards of any tight end in the league (325) and three touchdowns. The rookie second-round pick is the best tight end the Ravens have faced this season and Hamilton could be called on often to help neutralize the threat in a one-on-one matchup.

DT Michael Pierce vs. C Frank Ragnow

The Lions' offensive line is one of the best in the league, anchored by the two-time Pro Bowler in the middle. Detroit wants to establish the run, and Pierce will be a critical part of knocking it back. Ragnow is one of the league's biggest centers and Pierce is a big, strong defensive lineman.

CB Marlon Humphrey vs. WR Amon-Ra St. Brown

Humphrey didn't give up a single catch last week in London and now he's going against one of the best in the league in St. Brown, who ranks No.15 in the NFL with 455 receiving yards and No.13 with 38 receptions. St. Brown is a feisty, physical player and good route runner who drew comparisons to Anquan Boldin coming out of college. Humphrey is a physical corner who doesn't back down.

LB Patrick Queen vs. RB Jahmyr Gibbs

Lions running back David Montgomery is dealing with an injury, thrusting the rookie Gibbs into the starting lineup. Gibbs was the No.12-overall pick for a reason. He has homerun threat speed and is dangerous as a receiver. Queen will need his sideline-to-sideline speed to prevent any big plays.