CB Nate Wiggins vs. WR Chris Olave: Both Wiggins and Olave had exceptional performances in Week 1: Wiggins allowed no catches on two targets in 34 coverage snaps, per Next Gen Stats, while Olave tallied NFL highs in receptions (10) and reception yards (182).

OLB Trey Hendrickson vs. LT Kelvin Banks Jr.: After facing Lions outside linebacker Aidan Hutchinson, who tied for the NFL lead in pressures in Week 1 (10), Banks will face another tall task in blocking Hendrickson, who had eight pressures against the Colts.

OLB Tavius Robinson vs. RT Taliese Fuaga: Robinson and Fuaga are promising young pieces and physical tone-setters on their respective teams. Robinson led the Ravens in quarterback hits last week (4) and will present a tough challenge for Fuaga, a 2024 first-round pick.

RB Derrick Henry vs. Saints Run Defense: Against the Colts, Henry rumbled for 144 rushing yards and three touchdowns. The Saints gave up 156 yards and 5.4 yards per carry to Lions running back Jahmyr Gibbs in Week 1. If New Orleans can't flip the script from last week, Henry could have another big day on the ground.

Offensive Coordinator Declan Doyle vs. Saints Defensive Coordinator Brandon Staley: Doyle received heaps of praise after the Ravens totaled 506 yards of offense and 41 points against the Colts in his play-calling debut. Staley, however, captained a solid Saints defense in 2025 and is in his sixth season as a defensive play caller.