CB Marlon Humphrey vs. WR Amon-Ra St. Brown

St. Brown torched the Bears last week with nine catches for 115 yards and three touchdowns. The former fourth-round pick plays almost as much in the slot as he does outside (50 to 59 snaps) and is a third-down favorite for quarterback Jared Goff. Humphrey will need to know where he is at all times.

OLB Mike Green vs. RT Penei Sewell

Sewell is one of the top tackles in the league and a pivotal cog in the Lions' offensive machine. With Kyle Van Noy (hamstring) expected to be out, Green could be in line to make his first career start. The Ravens will need to generate pressure on Goff, and there's no better challenge for Green than going up against a three-time Pro Bowler.

ILB Roquan Smith vs. RB Jahmyr Gibbs

Smith is coming off arguably the best game of his career and he faces a tall task this week trying to contain Gibbs and the Lions' rushing attack. A dual-threat tailback, Gibbs can turn any touch he gets into an explosive play. He already has 13 receptions this season (just one fewer than Zay Flowers), so Smith and rookie Teddye Buchanan will be critical in pass coverage. Containing Gibbs is the key to keeping Detroit's offense under control.

RT Roger Rosengarten vs. DE Aidan Hutchinson

Hutchinson is back to looking like himself after last season's major leg injury. He had his first sack of the season against Chicago last week and finished with seven total pressures. In what could wind up being a shootout between two high-powered offenses, limiting Hutchinson's impact is a key to victory.

S Malaki Starks vs. WR Jameson Williams

Williams is one of the top deep threats in the league. He showcased his speed last week with a 64-yard catch-and-run and a 44-yard touchdown. Starks has yet to face off against a receiver with Williams' top-line speed, so Monday will be a true test of how the rookie holds up deep in coverage.