QB Lamar Jackson vs. S Minkah Fitzpatrick

Jackson will return to the lineup in his hometown of South Florida after missing the previous three games. The two-time MVP hasn't played since Week 4 against the Chiefs, and despite the short week, Jackson said he isn't concerned about knocking off any rust. He'll face a familiar foe in Fitzpatrick, who spent the last six seasons in Pittsburgh before being traded back to Miami this summer. Fitzpatrick intercepted Jackson last year when he was on the Steelers. Now, the two square off again.

CB Nate Wiggins vs. WR Jaylen Waddle

Wiggins had his second interception of the season against the Bears at a critical point in the fourth quarter. The second-year cornerback continues to match up with opposing teams' top pass catchers, and with Tyreek Hill out for the season, Waddle fits that bill in Miami. Waddle has become Tua Tagovailoa's go-to target, leading the team with 504 receiving yards and four touchdowns on 35 catches. Wiggins will try to limit the speedy wideout's opportunities.

ILB Roquan Smith vs. RB De'Von Achane

Smith was very impactful in his return from injury last week, finishing with a game-high 12 tackles and helping hold D'Andre Swift to just 45 rushing yards. With 539 yards on 107 carries, Achane is the engine of the Dolphins' offense. The lightning-fast tailback is just as much of a threat in the passing game as he is on the ground, as he leads Miami with 37 receptions, four of which were scores.

RB Derrick Henry vs. ILB Jordyn Brooks

With Jackson back in the fold, Henry's job should get easier. The 31-year-old tailback had 71 yards and two touchdowns on the ground last week and has reached the 100-yard mark twice this season. Brooks leads the league with 85 tackles and has 2.5 sacks. Miami is giving up the fifth most rushing yards per game (146), so Henry will have his chances to break away for long runs.

S Kyle Hamilton vs. QB Tua Tagovailoa

Since Alohi Gilman arrived in Baltimore, Hamilton has made a home near the line of scrimmage. Last week against the Bears, Hamilton aligned in the box on 61% of his snaps and blitzed on 24% of those, per Next Gen Stats, and forced an intentional grounding penalty. Tagovailoa leads all quarterbacks with 14 turnovers (10 interceptions, four fumbles) but had his best game of the season last week with four touchdown tosses and no giveaways.