WR Zay Flowers vs. CB Sauce Gardner: One of the league's ascending wideouts faces one of the league's top outside cornerbacks. Flowers is looking to make his third straight Pro Bowl, while Gardner is hoping to stay on the field after being limited by a calf injury late last season.

Ravens Interior Offensive Line vs. Colts Interior Defensive Line: The Colts have one of the NFL's best interior defensive line duos in DeForest Buckner and Grover Stewart. Center Jovaughn Gwyn and guard Vega Ioane, both of whom are slated for their first NFL starts on Sunday, will have a difficult opening matchup.

S Kyle Hamilton vs. TE Tyler Warren: Just like he did at Penn State, Warren lined up all over the Colts' formation in his rookie season. Hamilton, meanwhile, is one of the league's best do-it-all defensive backs who, like Warren, wears many different hats for his unit. Expect both players to move around often.

OLB Trey Hendrickson vs. T Bernhard Raimann: The Ravens will hope that Hendrickson can translate his dominant offseason into regular-season games. His first test as a Raven will come against Raimann, who's started almost every game for the Colts at left tackle over the past three seasons.

Head Coach Jesse Minter vs. Head Coach Shane Steichen: Steichen has been the Colts' offensive play caller and head coach since 2023. Minter, meanwhile, has only combined head coaching and defensive play calling duties for three preseason games. The latter will look for a get-back in his head coaching debut after the Colts hung 38 points on a Minter-led Chargers defense last season.