RT Roger Rosengarten vs. OLB T.J. Watt

In three games against the Steelers last season, Rosengarten allowed just one sack and 10 total pressures, helping hold Watt to one sack. The second-year tackle will again see plenty of Watt, who has seven sacks this season and is always capable of wrecking an offensive game plan. Especially with quarterback Lamar Jackson banged up, disrupting Watt's impact as a pass rusher will be critical.

OLB Mike Green vs. LT Andrus Peat

Green has come into his own over the last several weeks and leads the team with 11 quarterback hits. The second-round rookie will get his shot to bring down an immobile 42-year-old Aaron Rodgers, who is dealing with a left wrist injury. Pittsburgh will have its backup left tackle start after Broderick Jones was placed on injured reserve. Peat, an 11-year veteran who has been a guard most of his career, has started two games this year and gave up no pressures last week.

CB Marlon Humphrey vs. WR DK Metcalf

Humphrey and Nate Wiggins had a tough assignment with Ja'Marr Chase last week, and they'll have another challenge going up against Pittsburgh's top weapon. Metcalf, whom the Steelers traded for this offseason, leads his team in receptions (45), yards (605), and receiving touchdowns (five). No other Pittsburgh pass catcher has 300+ yards, so limiting Metcalf's big-play ability could keep the Steelers' offense from finding its rhythm.

S Kyle Hamilton vs. TE Darnell Washington

Hamilton is a do-it-all player, and with his frame and skillset, he may be the best man to defend Washington, who is a red-zone favorite of Rodgers. The 6-foot-7, 311-pound Washington is having his best season as a pass catcher with 276 yards and one touchdown on 22 receptions, 13 of which were for first downs. It'll likely take multiple defenders to bring down the burly Washington, so the entire defense will need to rally to the tight end whenever he receives the ball.

RB Derrick Henry vs. ILB Patrick Queen

In the last two games against the Steelers last year, including the Wild-Card playoff win, Henry rumbled for 348 yards and two touchdowns. After getting just 10 carries last game, Henry has an opportunity to have a strong game against a Pittsburgh defense that just gave up 249 rushing yards to the Bills. The matchup with the former Raven Queen is always intriguing. Henry ran past Queen on a 44-yard touchdown run in the playoffs last season.