The Ravens entered Sunday's game healthy, but they didn't depart it that way.
Tight end Mark Andrews went to the locker room in the first quarter with a right knee injury and did not return, taking a key piece away from Baltimore's offense.
Meanwhile, the Ravens also had two important special teams players go out with injuries – inside linebacker Chris Board (concussion) and safety Anthony Levine Sr. (ankle).
After the game, Head Coach John Harbaugh said that neither Andrews nor Levine had suffered major injuries.
"Mark is not serious, maybe a thigh bruise type of thing," Harbaugh said. "Anthony is not serious, ankle. Both those guys told me they'd be back Thursday. We'll see how that goes as the week goes on."
Andrews leads the team in both receptions (54) and receiving yards (707) and has emerged as one of the NFL's top pass-catching tight ends. He had one catch for 14 yards Sunday, but Andrews limped to the locker room after being attended to by medical personnel on the sideline.
Without Andrews, tight ends Nick Boyle and Hayden Hurst were relied upon to carry the load at tight end. Both stepped up in huge fashion, each catching a touchdown pass.
Boyle responded immediately, scoring Baltimore's first touchdown after catching a flip pass from Lamar Jackson, who improvised after scrambling. After initially juggling the pass from Jackson, Boyle gained possession for the 3-yard touchdown reception.
Hurst struck in the third quarter, getting behind Buffalo's defense and hauling in Jackson's pass for a 61-yard touchdown reception.
The Ravens, who have been relatively healthy this season, will hope Andrews, Levine and Board recover quickly.
Levine has been one of the Ravens' best special teams players for years, and he is also a versatile defensive player capable of playing both safety and linebacker in Defensive Coordinator Wink Martindale's packages.
Board was ruled out after being placed in concussion protocol late in the first quarter. Board is one of Baltimore's best special teams players and made tackles on each of Baltimore's first two kickoffs. Board also suffered a concussion during the preseason that knocked him out of action for weeks.
The injured players won't have much time to recover before Baltimore's next game, with the Ravens facing a short week before hosting the New York Jets on Thursday night.