G Vega Ioane vs. Titans DL Jeffery Simmons: Ioane's first start at center will require him to block an actual titan of the game in Simmons, a three-time All-Pro who's coming off career highs in sacks (11), tackles for loss (17), and quarterback hits (21) in a season.

CB Nate Wiggins vs. Titans WR Carnell Tate: The numbers (123 yards, zero touchdowns) may not show it, but Tate has looked plenty worthy of being the No. 4 pick in this year's NFL Draft through Tennessee's first three games. But he'll face a tough test against Wiggins, who allowed six receptions in man coverage against the Dallas Cowboys in Week 3, but also had a clutch pass breakup late in the fourth quarter.

RB Derrick Henry vs. Titans LB Anthony Hill Jr.: Hill Jr. leads the NFL in total tackles and was named the NFL's Defensive Rookie of the Month. Henry, who'll face his former team for the first time on Sunday, could give Hill Jr. a "Welcome to the NFL" moment if he reaches the second level.

OLB Tavius Robinson vs. Titans T JC Latham: The No. 7 pick in the 2024 NFL Draft, Latham has blossomed into one of the NFL's more promising right tackles. Robinson, meanwhile, has started this season strong with two sacks, six quarterback hits, and seven total tackles through three games.

Ravens Defense vs. Titans QB Cam Ward: Baltimore's defense is looking for a rebound after giving up 31 points and 415 yards of offense to the Cowboys in Week 3. The top pick in last year's NFL Draft, Ward is looking to lead Tennessee to its first win since Week 16 of last season.