Michael Pierce Is Back; 49ers' Top Running Back Out

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One of the Ravens' top run defenders is back to face the San Francisco 49ers, who love running the football.

Defensive tackle Michael Pierce (ankle) is active after a two-game absence and will rejoin the defensive line rotation. Pierce leads all Ravens defensive linemen in tackles and his presence will be welcomed against the 49ers (10-1), who have the NFL's second-ranked rushing attack (145.6 yards per game) behind only the Ravens. 

Rookie wide receiver Miles Boykin (ankle) is active and will be in the lineup after testing his ankle briefly during pre-game warmups in the rain. The third-round pick (11 catches, 185 yards, two touchdowns) has not missed a game this season. Boykin leads the Ravens in yards per catch (16.8) and is an excellent downfield blocker.

Everyone who was listed as questionable for the Ravens is active, including left guard Bradley Bozeman (ankle), defensive tackle Domata Peko (knee) and outside linebacker Matthew Judon (ankle). All of them were full participants in Friday's practice.

Offensive lineman Parker Ehinger is also active after being brought up from the practice squad Saturday Ehinger is likely to backup undrafted rookie center Patrick Mekari, who is expected to make his first career start. Mekari is replacing veteran center Matt Skura, who suffered a season-ending knee injury on Monday.

Baltimore's inactives are quarterback Trace McSorley, wide receiver Jaleel Scott, safety Bennett Jackson, guard Ben Powers, defensive tackle Zach Sieler, and cornerbacks Anthony Averett and Iman Marshall.

Matt Breida and Joe Staley Inactive for 49ers

San Francisco's leading rusher Matt Breida (542 yards) is inactive (ankle), which is a big loss for the 49ers. With Breida out of the lineup, the bulk of San Francisco's running load is likely to be carried by Tevin Coleman (448 yards) and Raheem Mostert (393 yards).

The 49ers are expected to rely heavily on their running attack in Sunday's rainy conditions, and Breida is averaging five yards per carry.

Veteran left tackle Joe Staley (finger) is also inactive, which could also negatively impact San Francisco's offense. Staley has played just three games this season but had hoped to play against the Ravens.

Other inactives for the 49ers are premier pass rusher Dee Ford (6.5 sacks), who was ruled out on Friday, quarterback C.J. Beathard, wide receiver Dante Pettis, kicker Chase McLaughlin and tight end Levine Toilolo.

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